Hi...i will suggest to connect your "highest speed" devices (hard drives, flash drives, webcams) on a short path (no hubs, if possible) leaving your slower devices (mice, modems, graphics tablets, printers) connected through 1 or more hubs.
Some devices draw their power from the USB port, in those cases make sure they are on a "primary port" or powered hub. Devices that have their own power supply will work fine on an unpowered hub.
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